Implantable neurostimulator with refractory stimulation

ABSTRACT

In some embodiments, a method comprises providing an electrical signal to a nerve to evoke an action potential. The nerve thereby enters a refractory period in which the nerve is in a refractory state. The method further comprises, during the refractory period, providing an electrical signal to the nerve thereby altering the refractory period of the nerve or non-target tissues.

BACKGROUND

Implantable neurostimulators are effective at treating various disorders such as epilepsy and depression. A neurostimulator is implanted in the patient and connected via one or more electrodes to a target nerve, such as the vagus nerve. Current from the electrical signal provided by the neurostimulator or action potentials evoked by the stimulated target nerve can propagate to a non-target nerve (including nerves nearby the target nerve as well as specific non-target fibers within the target nerve) and non-target muscle tissue adjacent to the electrodes. As a result, such nearby tissues may be stimulated thereby resulting in wasted energy that is non-therapeutic and which may in addition cause undesired side effects such as contractions of the muscle tissue. For example, it is possible for vagus nerve stimulation to excite the muscles at or near the patient's vocal cords thereby potentially causing hoarseness. While generally regarded as benign, the excitation of muscle tissue and the resultant hoarseness may be uncomfortable to the patient and is at any rate undesired, wasteful and non-therapeutic. Ameliorating the foregoing problems while improving the efficacy of the underlying therapy provided by the neurostimulator is desirable.

BRIEF SUMMARY

In accordance with at least one embodiment of the invention, an implantable medical device comprises a neurostimulator that provides a first electrical signal to a nerve (e.g., the vagus nerve) in a first, non-refractory period. The first electrical signal is adapted to induce action potentials in one or more target axons (fibers) of the nerve. The neurostimulator also provides a second electrical signal to the nerve during a second period in which one or more of the non-target tissues (e.g. adjacent muscles or non-target nerve fibers) are refractory. The second period may comprise at least a portion of one or both of an absolute refractory period and a relative refractory period for the non-target tissue. The second signal provided to the nerve during the refractory period causes the refractory period of the non-target tissue to be altered, i.e., extended or shortened, depending on the attributes of the second signal. Extending the refractory period ameliorates various side effects that might otherwise occur. Shortening the relative refractory period facilitates additional therapies to be implemented.

In accordance with some embodiments, a method comprises applying a first electrical signal to a nerve to evoke an action potential. As a result, the nerve enters a refractory period in which the nerve is refractory to further induction of action potentials. During the refractory period, the method also comprises providing a second electrical signal to the nerve thereby altering the refractory period.

In accordance with another embodiment, a method comprises applying a first electrical signal to a nerve to evoke an action potential. The first electrical signal or action potential evokes action potentials in non-target tissue. The non-target tissue thereafter enters a refractory period in which the non-target tissue is refractory to further induction of action potentials. During the refractory period, the method further comprises applying a second electrical signal to the nerve thereby altering the refractory period of the non-target tissue.

In accordance with another embodiment, an implantable neurostimulator comprises an electrical signal generator and an electrode coupled to the electrical signal generator. The electrode is adapted to couple to a nerve. The electrical signal generator applies a first electrical signal to a nerve to evoke an action potential. As a result, the nerve enters a refractory period in which the nerve is in a refractory state. During the refractory period, the electrical signal generator provides a second electrical signal to the nerve thereby altering the refractory period of the nerve.

In accordance with yet another embodiment, an implantable neurostimulator comprises an electrical signal generator and an electrode. The electrode is adapted to be coupled to the electrical signal generator and to a nerve to thereby provide therapy to a target nerve fiber. The electrical signal generator applies a first electrical signal to a nerve to evoke an action potential in the target nerve which causes an action potential to be evoked in a non-target nerve fiber or tissue. The non-target nerve fiber or tissue thereby enters a refractory period in which the non-target nerve fiber or tissue is in a refractory state. During the refractory period, the electrical signal generator applies a second electrical signal to the nerve fiber or tissue thereby altering the refractory period of the non-target nerve fiber or tissue.

BRIEF DESCRIPTION OF THE DRAWINGS

For a detailed description of exemplary embodiments of the invention, reference will now be made to the accompanying drawings in which:

FIG. 1 depicts, in schematic form, an implantable neurostimulator, in accordance with a preferred embodiment of the invention, implanted within a patient and programmable by an external programming system;

FIG. 2 shows an illustrative embodiment of the implantable neurostimulator of FIG. 1;

FIG. 3 illustrates a refractory period of an electrically-excitable tissue as comprising an absolute refractory period and a relative refractory period;

FIG. 4 illustrates an embodiment in which the relative refractory period is extended by providing an electrical signal during the relative refractory period;

FIG. 5 illustrates an embodiment in which particular types of nerve fibers are targeted for refractory period adjustment;

FIG. 6 illustrates an embodiment in which the refractory period is shortened via the application of an electrical signal with a different polarity than the polarity used to stimulate the nerve initially; and

FIG. 7 illustrates a method of adjusting a refractory period of a nerve or other non-target tissue in accordance with a preferred embodiment of the invention.

DETAILED DESCRIPTION

The following discussion is directed to various embodiments of the invention. Although one or more of these embodiments may be preferred, the embodiments disclosed should not be interpreted, or otherwise used, as limiting the scope of the disclosure, including the claims. In addition, one skilled in the art will understand that the following description has broad application, and the discussion of any embodiment is meant only to be exemplary of that embodiment, and is not intended to limit the scope of the disclosure, including the claims, to that embodiment.

FIG. 1 illustrates an implantable medical device (“IMD”) 10 implanted in a patient. The IMD 10 may be representative of any of a variety of medical devices. At least one preferred embodiment of the IMD 10 comprises a neurostimulator for stimulating a neural structure in a patient, particularly a neurostimulator for stimulating a patient's cranial nerve such as a vagus nerve 13. Although the IMD 10 is described below in terms of a vagus nerve stimulation (“VNS”) embodiment, the disclosure and claims that follow are not limited to VNS unless expressly noted, and may be applied to the stimulation of other tissues such as the trigeminal and/or glossopharyngeal nerves, or to other neural tissue such as one or more brain structures of the patient, spinal nerves, and other spinal structures, as well as various non-neural tissues and organs.

Referring still to FIG. 1, a lead assembly 16 comprising one or more leads is coupled to the IMD 10. The lead assembly 16 includes one or more electrodes, such as electrodes 12 and 14. Each lead assembly 16 has a proximal end that connects to the IMD 10. The electrodes 12, 14 are coupled to a distal end of the lead assembly. At least one electrode 12 or 14, and preferably an electrode pair (12 and 14), is used as a therapeutic electrode to deliver an electrical signal to target tissues such as the patient's vagus nerve 13. At least one electrode 12, 14 (preferably an electrode pair 12 and 14) may in some embodiments be used as a sensing electrode to detect electrical activity of target tissue (e.g., the vagus nerve 13). In alternative embodiments, separate sensing electrode(s) may be used. The housing (or “can”) of the IMD 10 may also be used as a stimulating or sensing electrode. Sensing electrodes may alternatively be omitted entirely.

FIG. 1 also illustrates an external device implemented as a programming system 20 for the IMD 10. The programming system 20 may comprise a personal computer, a handheld computer such as a personal digital assistant (PDA) device, or other suitable computing device consistent with the description contained herein, as well as a wand 28 used for transmitting and receiving signals to and from the IMD 10. In systems where the programming system 20 uses one or more channels in the Medical Implant Communications Service (MICS) bandwidths, the wand 28 may be omitted to permit more convenient communication between the programming system and the IMD 10. Methods and apparatus for communication between the IMD 10 and an external programming system 20 are known in the art, including telemetry via an RF communication link. Representative techniques for such communication are disclosed in U.S. Pat. No. 5,304,206, and U.S. Pat. No. 5,235,980, both incorporated herein by reference. The IMD 10 includes a transceiver (such as a coil) that permits signals to be communicated wirelessly between the programming system 20 and/or wand 28 and the IMD 10. The programming system 20 monitors the performance of the IMD 10 and downloads new executable operational programming (i.e., software) and/or therapy parameters into the IMD 10 to alter its operation as desired. In accordance with preferred embodiments of the invention and as further explained below, the programming system 20 downloads configuration parameters that cause the IMD 10 to extend or shorten the refractory period of either the nerve 13 being stimulated or non-target tissue in or near the nerve.

FIG. 2 shows a block diagram of a preferred embodiment of the IMD 10. As shown, the IMD 10 includes a power supply 30 (e.g., a battery), a stimulation and communication unit (“SCU”) 32, and a controller 34. The illustrative SCU 32 of FIG. 2 comprises a current generator 37 and a communication system 38. Under the control of controller 34, the current generator 37 of the SCU 32 generates an electrical signal (e.g., a programmable, constant current pulsed signal) to stimulate a target neural tissue in a patient. Further, under the control of controller 34, the communication system 38 of the SCU 32 telemeters data (e.g., therapy parameters) or operational programming (e.g., executable software) to/from the programming system 20. In the embodiment of FIG. 2, the battery 30 provides power for both the SCU 32 and the controller 34.

The controller 34 generally assists, controls, and/or programs the SCU 32. Controller 34 preferably comprises a processor 36 such as a low-power, mixed-signal microcontroller. One suitable processor is available from Texas Instruments, Inc., selected from the MSP430F family of processors. Other suitable processors from the PIC1xF family of processors are available from MicroChip Technology. Other suitable processors may be used and/or integrated into the controller 34, although the processor 36 preferably is capable of processing a variety of sensor inputs, uses low power, and operates at a high speed. In general, however, any suitable processor 36 can be used in the controller 34 to implement the functionality performed by the controller 34 as explained herein. It will be appreciated that some features of the controller 34 may also be provided in whole or in part by the SCU 32, and vice versa. Thus, while certain features of preferred embodiments of the present invention may be described as comprising part of the SCU 32, it is not intended thereby to preclude embodiments in which the features are provided by the controller 34. Likewise, certain features described herein as comprising part of the controller 34 are not intended to preclude embodiments in which the features comprise part of the SCU 32.

In the embodiment of FIG. 2, the controller 34 additionally comprises a memory 40 integrated into the controller. In some embodiments, the processor 36 of the controller 34 directly executes programs from the integrated memory 40. That is, executable instructions (i.e., operational programming) can be fetched directly from memory 40 for execution by the processor 36 without first copying the instructions to another memory (e.g., a RAM). The integrated memory 40 may be upgraded by erasing one or more segments of the integrated memory 40 and, via the programmer 20, writing a new program to the integrated memory 40.

The external programming system 20 can wirelessly transmit programs and configuration data to the IMD 10 for storage in the IMD's memory 40, registers internal to the processor 36, or other storage of the IMD 10.

Like all electrically-excitable tissue, neural tissue, such as the vagus nerve, has an intrinsic property called the “refractory period.” Once a nerve is excited (i.e., an action potential is generated), the nerve enters the refractory period during which time the nerve is resistant to further induction of action potentials, even if another or additional electrical current is applied to the nerve. During this time period, the nerve is said to be “refractory” to an applied electrical signal. In general, action potentials can again be induced in the nerve with an applied electrical signal once the refractory period is over.

As illustrated by FIG. 3, the refractory period comprises an “absolute” refractory period followed by a “relative” refractory period. The absolute refractory period begins upon the stimulation of a nerve at 50. During the absolute refractory period, the nerve cannot be induced to generate an action potential regardless of the strength of the applied electrical signal. During the relative refractory period, which immediately follows the absolute refractory period, it is possible to induce an action potential in the nerve with a sufficiently strong applied electrical signal. A stronger electrical signal is required to generate an action potential during the relative refractory period than to initially stimulate the nerve during a non-refractory period. The lengths of the absolute and relative refractory periods may be altered by applying an electrical signal to the nerve during one or both of the absolute and relative refractory periods. The duration of the absolute and relative refractory periods without an externally applied signal are relatively constant for a particular tissue, and are referred to herein as the “intrinsic” absolute and relative refractory periods. The nerve's intrinsic relative refractory period ends at reference numeral 53 in FIG. 3.

Muscle tissue (e.g., the heart) is also characterized by a refractory period. Different types of muscular and neural tissues have different refractory periods. The refractory period of cardiac tissue tends to be substantially longer than the refractory period of neural tissue. Further, the vagus nerve comprises different types of nerve fibers, e.g., A fibers, B fibers and C fibers, with many subtypes. A and B vagus nerve fibers have larger diameters than C fibers. C fibers tend to have substantially longer refractory periods than A and B fibers, and B fibers have slightly longer refractory periods than A fibers.

Without limiting the scope of this disclosure, Table I below provides exemplary values for the absolute and relative refractory periods of various types of nerves and tissues. In general muscle tissues have substantially longer refractory periods than nerve tissues.

TABLE I Absolute Refractory Relative Refractory Tissue type (mS) (mS) Large diameter nerve 0.4 Up to 1.6 (e.g., A and B fiber types) Small diameter nerve 4 Up to 16 (e.g., C fiber type) Cardiac muscle 100 Up to 400

In accordance with various embodiments of the invention, the IMD 10 alters the length of the refractory period and, in some embodiments, specifically the relative refractory period. In some embodiments, the IMD 10 extends the relative refractory period, while in other embodiments, the IMD 10 shortens the relative refractory period. Further still, in some embodiments, the IMD 10 extends the relative refractory period in accordance with some therapies or situations, while shortening the relative refractory in accordance with other therapies or situations. Extending a relative refractory period can be accomplished by providing an electrical signal to the nerve during the relative refractory period at a level low enough so as not to re-stimulate the nerve. Shortening the relative refractory period can be accomplished by providing a signal during the relative refractory period with a polarity opposite to that of the first electrical signal that induced the action potential.

FIG. 4 depicts a timeline in which a second electrical signal 55 to alter the refractory period of the nerve is applied to the nerve beginning at a time in the relative refractory period of the nerve. The end of the nerve's intrinsic relative refractory period (53) is extended due to the application of the signal at 55. The relative refractory period can be extended almost indefinitely as long as the signal continues to be or is repetitively applied. However, the tissue will eventually either exit a refractory state or become permanently damaged or impaired, even with an applied current. Once the application of the signal is removed, the relative refractory period of the nerve will subsequently end, after which the nerve returns to a non-refractory state in which action potentials can again be induced with a first electrical signal.

Extending the relative refractory is useful to ameliorate side effects that might otherwise be caused by the IMD 10. For example, action potentials generated by applying a first electrical signal to a vagus nerve of a patient may propagate to adjacent muscle tissues. Such muscle tissues may include muscles adjacent to, or that directly control, the patient's vocal cords. As a result of stimulating the patient's vagus nerve, the patient's vocal cords, or controlling muscles, may be affected possibly resulting in hoarseness or changes to the patient's voice during delivery of a first electrical signal. All tissues stimulated by the first electrical signal, including both target nerve fibers and non-target nerve fibers or muscles, will begin their respective intrinsic refractory periods approximately synchronous with the first electrical signal. However, the difference between intrinsic refractory periods of different tissues may be exploited to ameliorate undesired side effects.

In accordance with at least some embodiments, the current generator 37 of the IMD 10 provides a second electrical signal during the relative refractory period of at least one non-target tissue, such as a particular nerve fiber type, or muscle tissue. The magnitude of the second electrical signal is small enough to prevent additional action potentials from being generated. Instead, the second electrical signal provided to the nerve causes the non-target tissue, which is in a refractory state, to remain in a refractory state, thereby extending the duration of the relative refractory period. By extending the relative refractory period of the non-target tissue, no additional action potentials will be induced that otherwise would propagate to, and stimulate, adjacent tissues. In at least some such embodiments, the relative refractory period is extended as long as the second electrical signal continues to be applied to the nerve.

The magnitude of the second electrical signal used to extend the relative refractory period depends, at least in part, on the point in time during the relative refractory period at which the second electrical signal is first applied to the nerve. The earlier in the relative refractory period that the second electrical signal is applied, the larger the magnitude the second electrical signal needs to be to cause the relative refractory period to be extended. By contrast, the later in the relative refractory period that the current is applied, the smaller the magnitude of the current needs to be to cause the relative refractory period to be extended.

FIG. 5 illustrates refractory periods for two different types of nerve fibers—large diameter fibers (e.g., A and B fibers) and small diameter fibers (e.g., C fibers). The refractory period for the small fiber type is longer than the refractory period of the large fiber type. In FIG. 5, it can be seen that it is possible to apply a second electrical signal to the nerve (comprising both fiber types) at a point in time (e.g., 60) that falls within the relative refractory period of the small diameter fibers, and yet falls outside the relative refractory period of the large diameter fibers. A second electrical signal applied at point 60 of an appropriate magnitude will extend the relative refractory period of the small diameter fibers. Because the second electrical signal occurs after the end of the relative refractory period of the large diameter fibers, it may still be used for stimulation of the large fibers. That is, the second electrical signal does not extend the relative refractory period of the large fibers (thereby allowing action potentials to occur) and does extend the relative refractory period in the small fibers (thereby precluding action potentials from occurring). As a result, the relative refractory period of selected fiber types can be extended. To the extent the fiber types whose relative refractory periods are selectively extended would otherwise cause various side effects, such side effects can be reduced or eliminated by keeping the selected fiber types in a relative refractory state.

FIG. 6 illustrates the shortening of the intrinsic relative refractory period of a nerve via the application of a reverse polarity second electrical signal during the nerve's relative refractory period. A reverse polarity second electrical signal means that the current flows in the opposite direction than the direction of current flow in the first, therapeutic electrical signal applied at 50. As illustrated in FIG. 6, the end 53 of the nerve's intrinsic relative refractory period is shortened to 62 via the application of a reverse polarity current beginning at time 64 during the relative refractory period. The amount of time 65 by which the refractory period is shortened is a function of the magnitude and time duration of the reverse polarity second electrical signal.

Shortening the relative refractory period of a nerve causes the nerve to be available to be re-stimulated sooner than otherwise would be possible. As a result, therapies are possible in which the nerve can be stimulated a faster rate than without the use of the second electrical signal. Further, as illustrated in FIG. 5, some fiber types have longer refractory periods than other fiber types. By applying a reverse polarity current during the refractory period of the fiber types having the longer refractory periods (e.g., the small fiber types), the refractory periods of such fibers can be shortened and made substantially the same as, or at least closer to, the refractory periods of the fiber types having the intrinsically smaller relative refractory periods.

FIG. 7 shows a method 80 of altering the refractory period of a nerve in accordance with an embodiment of the invention. At 82, method 80 comprises applying a first electrical signal in a nerve during a non-refractory period. The first electrical signal is selected to induce an action potential in the nerve, as shown at 84. Following the induced action potential, the method further comprises applying (step 86) a second electrical signal to the nerve during a refractory period of the non-target nerve/nerve fibers or non-target tissue. The second electrical signal alters the length of the refractory period (step 88). As discussed above, the alteration to the nerve's or non-target tissue's relative refractory period can be to extend or shorten the relative refractory period.

In accordance with at least some embodiments of the invention, the external programming system 20 (FIG. 1) can be used to program the IMD 10 to shorten or extend the nerve's or non-target tissue's relative refractory period. Via the programming system 20, one or more parameters are transmitted to the IMD 10 that cause the current generator 37 of the IMD 10 to provide an appropriate current to the nerve during the nerve's or non-target tissue's relative refractory period so as to shorten or lengthen the refractory period as desired.

The above discussion is meant to be illustrative of the principles and various embodiments of the present invention. Numerous variations and modifications will become apparent to those skilled in the art once the above disclosure is fully appreciated. It is intended that the following claims be interpreted to embrace all such variations and modifications. 

1. A method, comprising: applying a first electrical signal to a nerve to evoke an action potential, said nerve thereafter entering a refractory period in which the nerve is refractory to further induction of action potentials; and during said refractory period, applying a second electrical signal to said nerve thereby altering said refractory period.
 2. The method of claim 1 wherein providing said second electrical signal during said refractory period comprises providing current during a relative refractory period.
 3. The method of claim 1 wherein providing said second electrical signal during said refractory period comprises providing current for a period of time that extends past the nerve's intrinsic refractory period.
 4. The method of claim 1 wherein said refractory period comprises an absolute refractory period and a relative refractory period, and wherein applying said second electrical signal to said nerve during said refractory period comprises beginning to apply said second electrical signal to said nerve during said relative refractory period.
 5. The method of claim 1 wherein applying said first electrical signal to said nerve comprises applying an electrical signal having a first polarity and wherein applying said second electrical signal comprises applying an electrical signal having a different polarity than said first polarity, thereby shortening said refractory period of said nerve.
 6. The method of claim 1 wherein applying said first electrical signal to said nerve comprises applying an electrical signal having a first polarity and wherein applying said second electrical signal comprises applying an electrical signal having the same polarity as the first polarity, thereby extending said refractory period of said nerve.
 7. The method of claim 1 wherein applying said second electrical signal to said nerve comprises applying said second electrical signal during a relative refractory period of a select nerve fiber type while not applying said second electrical signal during the refractory period of another nerve fiber type.
 8. The method of claim 1 wherein applying said second electrical signal to said nerve comprises applying an electrical signal at a magnitude insufficient to generate an action potential.
 9. A method, comprising: applying a first electrical signal to a nerve to evoke an action potential; wherein said first electrical signal or said action potential evokes action potentials in non-target tissue; said non-target tissue thereafter entering a refractory period in which the non-target tissue is refractory to further induction of action potentials; and during said refractory period, applying a second electrical signal to said nerve thereby altering said refractory period of the non-target tissue.
 10. The method of claim 9 wherein providing said second electrical signal during said refractory period comprises providing current during a relative refractory period.
 11. The method of claim 9 wherein providing said second electrical signal during said refractory period comprises providing current for a period of time that extends past the non-target tissue's intrinsic refractory period.
 12. The method of claim 9 wherein said refractory period comprises an absolute refractory period and a relative refractory period, and wherein applying said second electrical signal to said nerve during said refractory period comprises beginning to apply said second electrical signal to said nerve during said relative refractory period.
 13. The method of claim 9 wherein applying said first electrical signal to said nerve comprises applying an electrical signal having a first polarity and wherein applying said second electrical signal comprises applying an electrical signal having a different polarity than said first polarity, thereby shortening said refractory period.
 14. The method of claim 9 wherein applying said first electrical signal to said nerve comprises applying an electrical signal having a first polarity and wherein applying said second electrical signal comprises applying an electrical signal having the same polarity as the first polarity, thereby extending said refractory period.
 15. The method of claim 9 wherein applying said second electrical signal to said nerve comprises applying said second electrical signal during a relative refractory period of a select nerve fiber type while not applying said second electrical signal during the refractory period of another nerve fiber type.
 16. The method of claim 9 wherein applying said second electrical signal to said nerve comprises applying an electrical signal at a magnitude insufficient to generate an action potential.
 17. An implantable neurostimulator, comprising: an electrical signal generator; and an electrode coupled to said electrical signal generator and adapted to couple to a nerve; wherein said electrical signal generator applies a first electrical signal to a nerve to evoke an action potential, said nerve thereby entering a refractory period in which the nerve is in a refractory state, and during said refractory period, said electrical signal generator applies a second electrical signal to said nerve thereby altering said refractory period.
 18. The implantable neurostimulator of claim 17 wherein said electrical signal generator extends said refractory period of said nerve.
 19. The implantable neurostimulator of claim 17 wherein said electrical signal generator extends a relative refractory period of said nerve.
 20. The implantable neurostimulator of claim 17 wherein said electrical signal generator shortens said refractory period of said nerve.
 21. The implantable neurostimulator of claim 17 wherein said electrical signal generator shortens a relative refractory period of said nerve.
 22. The implantable neurostimulator of claim 17 wherein said electrical signal generator applies said second electrical signal during a refractory period of a select nerve fiber type while not applying said second electrical signal during the refractory period of another nerve fiber type.
 23. An implantable neurostimulator, comprising: an electrical signal generator; and an electrode coupled to said electrical signal generator and adapted to couple to a nerve to thereby provide therapy to a target nerve fiber; wherein said electrical signal generator applies a first electrical signal to a nerve to evoke an action potential in the target nerve which causes an action potential to be evoked in a non-target nerve fiber or tissue, said non-target nerve fiber or tissue thereby entering a refractory period in which the non-target nerve fiber or tissue is in a refractory state, and during said refractory period, said electrical signal generator applies a second electrical signal to said target nerve thereby altering said refractory period of said non-target nerve fiber or tissue.
 24. The implantable neurostimulator of claim 23 wherein said first and second electrical signals have opposite polarities to each other and said refractory period is thereby shortened.
 25. The implantable neurostimulator of claim 23 wherein said first and second electrical signals have a common polarity to each other and said refractory period is thereby extended. 